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Activation of DNA damage response by antitumor therapy counteracts the activity of vinca alkaloids.
Anticancer Res. 33, 5273-5287 (2013)
Background/Aim: Anthracyclines have been proven able to reduce the activity of vinca alkaloids by induction of cell-cycle arrest. The present study aims at identifying the critical initiation steps of signal transduction which transduce the inhibitory effects on the cytotoxicity of vinca alkaloids. MATERIALS AND METHODS: Several new cytostatic drug classes were evaluated together with vincristine in tumor cell lines and patients' tumor cells. RNA interference was used for molecular analyses. RESULTS: Inhibition of vincristine was observed by all cytostatic drugs, which induced cell-cycle arrest. Knockdown of proteins of the DNA damage response ascribed the inhibitory effect to a common pathway involving Chk-1, p53 and p21. Upstream of Chk-1 signal transduction depended on both ATM and ATR for all drugs except methotrexate. CONCLUSION: We have identified critical signaling steps of the DNA damage response system activated by cytostatic drugs, which reduce the anti-tumor activity of vinca alkaloids. The obtained results encourage the development of novel therapeutic strategies to prevent pathway interactions based on the molecular understanding of drug action and drug-drug interactions.
Impact Factor
Scopus SNIP
Altmetric
1.713
0.701
Anmerkungen
Besondere Publikation
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
ATM; ATR; Chk1; DNA damage; cell-cycle arrest; p21; p53; vinca alkaloids; Cell-cycle Arrest; Cancer-therapy; Tumor-cells; P53; Checkpoints; Death; Anthracyclines; Proliferation; Mechanisms; Caspase-8
Sprache
Veröffentlichungsjahr
2013
HGF-Berichtsjahr
2013
ISSN (print) / ISBN
0250-7005
e-ISSN
1791-7530
Zeitschrift
Anticancer Research
Quellenangaben
Band: 33,
Heft: 12,
Seiten: 5273-5287
Verlag
International Institute of Anticancer Research
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Gene Vector (AGV)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-501590-001
PubMed ID
24324060
WOS ID
WOS:000328801900008
Erfassungsdatum
2013-12-12