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Weißbrich, B.* ; Nauerth, M.* ; Busch, D.H.

Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.

OncoImmunology 2:e26199 (2013)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Editorial
Korrespondenzautor
Schlagwörter T cell; CD8+ cytotoxic T cell; T cell receptor; Avidity; Koff rate
ISSN (print) / ISBN 2162-4011
e-ISSN 2162-402X
Zeitschrift OncoImmunology
Quellenangaben Band: 2, Heft: 10, Seiten: , Artikelnummer: e26199 Supplement: ,
Verlag Taylor & Francis
Verlagsort Philadelphia
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Antigen-specific Immunotherapy (VIRO-KVA)
Institute of Molecular Immunology (IMI)