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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells.
FEBS Lett. 582, 3729-3733 (2008)
The transport protein particle (TRAPP) complex is required for proper vesicular transport from the ER to the Golgi. The composition of yeast TRAPP is well characterized, but the organization of mammalian TRAPP complex remains elusive. Using a tandem affinity purification (TAP) approach, we provide first experimental proof for the association of NIBP (NIK/IKKbeta binding protein) with Bet3 and find two human paralogs of Trs33 (A and B) associated with Bet3. Interaction studies and gel filtration analysis reveal that both proteins are part of human TRAPP and might mark two distinct isocomplexes that exert different functions in the regulation of ER-to-Golgi traffic.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Vesicular transport; TRAPP; Golgi; Bet3; Trs33
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Zeitschrift
FEBS Letters
Quellenangaben
Band: 582,
Heft: 27,
Seiten: 3729-3733
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Signaling and Translation (SAT)