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Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells.
FEBS Lett. 582, 3729-3733 (2008)
The transport protein particle (TRAPP) complex is required for proper vesicular transport from the ER to the Golgi. The composition of yeast TRAPP is well characterized, but the organization of mammalian TRAPP complex remains elusive. Using a tandem affinity purification (TAP) approach, we provide first experimental proof for the association of NIBP (NIK/IKKbeta binding protein) with Bet3 and find two human paralogs of Trs33 (A and B) associated with Bet3. Interaction studies and gel filtration analysis reveal that both proteins are part of human TRAPP and might mark two distinct isocomplexes that exert different functions in the regulation of ER-to-Golgi traffic.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Altmetric
3.263
0.950
16
Anmerkungen
Besondere Publikation
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Vesicular transport; TRAPP; Golgi; Bet3; Trs33
Sprache
englisch
Veröffentlichungsjahr
2008
HGF-Berichtsjahr
2008
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Zeitschrift
FEBS Letters
Quellenangaben
Band: 582,
Heft: 27,
Seiten: 3729-3733
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Signaling and Translation (SAT)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e)
G-509800-002
Erfassungsdatum
2008-12-16