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Epithelial-mesenchymal transition in lung development and disease: Does it exist and is it important?
Thorax 69, 760-765 (2014)
Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question-namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)-is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Idiopathic Pulmonary-fibrosis; Growth-factor-beta; Transcription Factor Slug; Smooth-muscle-cells; Tgf-beta; Cigarette-smoke; Extracellular-matrix; Airway; Asthma; Cancer
ISSN (print) / ISBN
0040-6376
e-ISSN
1468-3296
Zeitschrift
Thorax
Quellenangaben
Band: 69,
Heft: 8,
Seiten: 760-765
Verlag
BMJ Publishing Group
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Health and Immunity (LHI)