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Campa, A. ; Alloni, D. ; Antonelli, E. ; Ballarini, E. ; Belli, M. ; Dini, V. ; Esposito, G. ; Facoetti, A. ; Friedland, W. ; Furusawa, Y. ; Liotta, M. ; Ottolenghi, A. ; Paretzke, H.G. ; Simone, G. ; Sorrentino, E. ; Tabocchini, M.A.

DNA fragmentation induced in human fibroblasts by ⁵⁶Fe ions: Experimental data and Monte Carlo simulations.

Radiat. Res. 171, 438-445 (2009)
Verlagsversion DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We studied the DNA fragmentation induced in human fibroblasts by iron-ion beams of two different energies: 115 MeV/nucleon and 414 MeV/nucleon. Experimental data were obtained in the fragment size range 1-5700 kbp; Monte Carlo simulations were performed with the PARTRAC code; data analysis was also performed through the Generalized Broken Stick (GBS) model. The comparison between experimental and simulated data for the number of fragments produced in two different size ranges, 1-23 kbp and 23-5700 kbp, gives a satisfactory agreement for both radiation qualities. The Monte Carlo simulations also allow the counting of fragments outside the experimental range: The number of fragments smaller than 1 kbp is large for both beams, although with a strong difference between the two cases. As a consequence, we can compute different RBEs depending on the size range considered for the fragment counting. The PARTRAC evaluation takes into account fragments of all sizes, while the evaluation from the experimental data considers only the fragments in the range of 1-5700 kbp. When the PARTRAC evaluation is restricted to this range, the agreement between experimental and computed RBE values is again good. When fragments smaller than 1 kbp are also considered, the RBE increases considerably, since gamma rays produce a small number of such fragments. The analysis performed with the GBS model proved to be quite sensitive to showing, with a phenomenological single parameter, variations in double-strand break (DSB) correlation.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter double-strand breaks; field gel-electrophoresis; linear-energy-transfer; heat-labile sites; ionizing-radiation; v79 cells; critical lesions; light-ions; damage; distributions
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0033-7587
e-ISSN 1938-5404
Zeitschrift Radiation Research
Quellenangaben Band: 171, Heft: 4, Seiten: 438-445 Artikelnummer: , Supplement: ,
Verlag Radiation Research Society
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501100-004
PubMed ID 19397444
DOI 10.1667/RR1442.1
Scopus ID 66149130747
Erfassungsdatum 2009-12-31
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