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Macherius, A.* ; Seiwert, B.* ; Schröder, P. ; Huber, C. ; Lorenz, W.* ; Reemtsma, T.*

Identification of plant metabolites of environmental contaminants by UPLC-QToF-MS: The in vitro metabolism of triclosan in horseradish.

J. Agric. Food Chem. 62, 1001-1009 (2014)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Plants can extensively transform contaminants after uptake through phase I and phase II metabolism to a large diversity of products. UPLC-QToF-MS was used to detect and identify metabolites of the bacteriostatic agent triclosan in a horseradish hairy root culture. Thirty-three metabolites of triclosan were recognized by a stepwise approach of mass defect filtering, multivariate data analysis, and isotope pattern filtering from a data set of several thousands of signals in the exposed culture. Structure proposals were elaborated for 23 triclosan metabolites on the basis of their MS data. The majority were identified as conjugates (phase II metabolites) such as saccharides or sulfosaccharides. Additionally, a disulfosaccharide was identified as a plant metabolite for the first time. Besides that, also conjugates of a phase I metabolite, hydroxytriclosan, were determined in horseradish tissue extracts. Dehalogenation products of triclosan were not observed. The large number of metabolites detected and identified in this study emphasizes the importance of a comprehensive analytical approach in studies on the uptake and fate of organic contaminants in plants.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Hydroxylation ; Opls-da ; Plant Metabolism ; Triclosan ; Uplc-qtof-ms; Resolution Mass-spectrometry; Personal Care Products; Municipal Biosolids; Soils; Pharmaceuticals; Elucidation; Cotton; Fate
ISSN (print) / ISBN 0021-8561
e-ISSN 1520-5118
Zeitschrift Journal of Agricultural and Food Chemistry
Quellenangaben Band: 62, Heft: 5, Seiten: 1001-1009 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Verlagsort Washington
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Microbe-Plant Interactions (AMP)