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Xapelli, S.* ; Agasse, F.* ; Grade, S. ; Bernardino, L.* ; Ribeiro, F.F.* ; Schitine, C.S.* ; Heimann, A.S.* ; Ferro, E.S.* ; Sebasti, A.M.* ; de Melo Reis, R.A.* ; Malva, J.O.*

Modulation of subventricular zone oligodendrogenesis: A role for hemopressin?

Front. Cell. Neurosci. 8:59 (2014)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Neural stem cells (NSCs) from the subventricular zone (SVZ) have been indicated as a source of new oligodendrocytes to use in regenerative medicine for myelin pathologies. Indeed, NSCs are multipotent cells that can self-renew and differentiate into all neural cell types of the central nervous system. In normal conditions, SVZ cells are poorly oligodendrogenic, nevertheless their oligodendrogenic potential is boosted following demyelination. Importantly, progressive restriction into the oligodendrocyte fate is specified by extrinsic and intrinsic factors, endocannabinoids being one of these factors. Although a role for endocannabinoids in oligodendrogenesis has already been foreseen, selective agonists and antagonists of cannabinoids receptors produce severe adverse side effects. Herein, we show that hemopressin (Hp), a modulator of CB1 receptors, increased oligodendroglial differentiation in SVZ neural stem/progenitor cell cultures derived from neonatal mice. The original results presented in this work suggest that Hp and derivates may be of potential interest for the development of future strategies to treat demyelinating diseases.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Herausgeber Gonzalez-Perez, O.*
Korrespondenzautor
Schlagwörter Endocannabinoids ; Hemopressin ; Myelin Pathologies ; Oligodendrogenesis ; Subventricular Zone; Neural Stem-cells; Cb1 Cannabinoid Receptors; Progenitor Cells; Multiple-sclerosis; Endocannabinoid System; Glial Progenitors; Corpus-callosum; Precursor Cells; White-matter; Adult Brain
e-ISSN 1662-5102
Zeitschrift Frontiers in Cellular Neuroscience
Quellenangaben Band: 8, Heft: , Seiten: , Artikelnummer: 59 Supplement: ,
Verlag Frontiers
Verlagsort Lausanne
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)