Schikowski, T.* ; Adam, M.* ; Marcon, A.* ; Cai, Y.* ; Vierkötter, A.* ; Carsin, A.E.* ; Jacquemin, B.* ; Al Kanani, Z.* ; Beelen, R.* ; Birk, M. ; Bridevaux, P.O.* ; Brunekeef, B.* ; Burney, P.* ; Cirach, M.* ; Cyrys, J. ; de Hoogh, K.* ; de Marco, R.* ; de Nazelle, A.* ; Declercq, C.* ; Forsberg, B.* ; Hardy, R.* ; Heinrich, J. ; Hoek, G.* ; Jarvis, D.* ; Keidel, D.* ; Kuh, D.* ; Kuhlbusch, T.* ; Migliore, E.* ; Mosler, G.* ; Nieuwenhuijsen, M.J.* ; Phuleria, H.* ; Rochat, T.* ; Schindler, C.* ; Villani, S.* ; Tsai, M.Y.* ; Zemp, E.* ; Hansell, A.* ; Kauffmann, F.* ; Sunyer, J.* ; Probst-Hensch, N.* ; Krämer, U.* ; Künzli, N.*
Association of ambient air pollution with the prevalence and incidence of COPD.
Eur. Respir. J. 44, 614-626 (2014)
The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain.The aim was to assess the impact of chronic exposure to air pollution on COPD in four cohorts using the standardised ESCAPE exposure estimates. Annual average particulate matter (PM), nitrogen oxides (NOx) and road traffic exposure were assigned to home addresses using land-use regression models. COPD was defined by NHANES reference equation (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) less than the lower limit of normal) and the Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC <0.70) and categorised by severity in non-asthmatics.We included 6550 subjects with assigned NOx and 3692 with PM measures. COPD was not associated with NO2 or PM10 in any individual cohort. In meta-analyses only NO2, NOx, PM10 and the traffic indicators were positively, although not significantly, associated with COPD. The only statistically significant associations were seen in females (COPD prevalence using GOLD: OR 1.57, 95% CI 1.11-2.23; and incidence: OR 1.79, 95% CI 1.21-2.68).None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments.
Impact Factor
Scopus SNIP
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Times Cited
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Cited By
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Obstructive Pulmonary-disease; Respiratory-health-survey; Long-term Exposure; Lung-function; Risk-factors; Cohort; Epidemiology; Population; Adults; Areas
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2014
Prepublished im Jahr
HGF-Berichtsjahr
2014
ISSN (print) / ISBN
0903-1936
e-ISSN
1399-3003
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 44,
Heft: 3,
Seiten: 614-626
Artikelnummer: ,
Supplement: ,
Reihe
Verlag
European Respiratory Society
Verlagsort
Sheffield
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
Hochschulort
Fakultät
Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
Anmeldeland
Priorität
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)
POF Topic(s)
30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-503900-001
G-504000-004
Förderungen
Copyright
Erfassungsdatum
2014-03-11