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möglich sobald bei der ZB eingereicht worden ist.
Hymenoptera allergens: From venom to "venome".
Front. Immunol. 5:77 (2014)
In Western Europe, Hymenoptera venom allergy (HVA) primarily relates to venoms of the honeybee and the common yellow jacket. In contrast to other allergen sources, only a few major components of Hymenoptera venoms had been characterized until recently. Improved expression systems and proteomic detection strategies have allowed the identification and characterization of a wide range of additional allergens. The field of HVA research has moved rapidly from focusing on venom extract and single major allergens to a molecular understanding of the entire "venome" as a system of unique and characteristic components. An increasing number of such components has been identified, characterized regarding function, and assessed for allergenic potential. Moreover, advanced expression strategies for recombinant production of venom allergens allow selective modification of molecules and provide insight into different types of immunoglobulin E reactivities and sensitization patterns. The obtained information contributes to an increased diagnostic precision in HVA and may serve for monitoring, re-evaluation, and improvement of current therapeutic strategies.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
0.000
0.824
7
58
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Allergen Components ; Allergy ; Cross-reactivity ; Insect Venom ; Recombinant Allergens ; Sensitization
Sprache
englisch
Veröffentlichungsjahr
2014
HGF-Berichtsjahr
2014
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Zeitschrift
Frontiers in Immunology
Quellenangaben
Band: 5,
Artikelnummer: 77
Verlag
Frontiers
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)
POF Topic(s)
80000 - German Center for Lung Research
Forschungsfeld(er)
Allergy
PSP-Element(e)
G-501800-541
PubMed ID
24616722
Erfassungsdatum
2014-03-26