Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques.
    
    
        
    
    
        
        Proc. SPIE 7899:789905 (2011)
    
    
    
		
		
			
				In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.
			
			
				
			
		 
		
			
				
					
					Impact Factor
					Scopus SNIP
					Web of Science
Times Cited
					Scopus
Cited By
					
					Altmetric
					
				 
				
			 
		 
		
     
    
        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
    
        Typ der Hochschulschrift
        
    
 
    
        Herausgeber
        
    
    
        Schlagwörter
        
    
 
    
        Keywords plus
        
    
 
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2011
    
 
    
        Prepublished im Jahr 
        
    
 
    
        HGF-Berichtsjahr
        0
    
 
    
    
        ISSN (print) / ISBN
        0277-786X
    
 
    
        e-ISSN
        1996-756X
    
 
    
        ISBN
        
    
 
    
        Bandtitel
        
    
 
    
        Konferenztitel
        Photons Plus Ultrasound: Imaging and Sensing 2011
    
 
	
        Konferzenzdatum
        January 22, 2011
    
     
	
        Konferenzort
        San Francisco, California, USA
    
 
	
        Konferenzband
        
    
 
     
		
    
        Quellenangaben
        
	    Band: 7899,  
	    Heft: ,  
	    Seiten: ,  
	    Artikelnummer: 789905 
	    Supplement: ,  
	
    
 
  
        
            Reihe
            
        
 
        
            Verlag
            SPIE
        
 
        
            Verlagsort
            
        
 
	
        
            Tag d. mündl. Prüfung
            0000-00-00
        
 
        
            Betreuer
            
        
 
        
            Gutachter
            
        
 
        
            Prüfer
            
        
 
        
            Topic
            
        
 
	
        
            Hochschule
            
        
 
        
            Hochschulort
            
        
 
        
            Fakultät
            
        
 
    
        
            Veröffentlichungsdatum
            0000-00-00
        
 
         
        
            Anmeldedatum
            0000-00-00
        
 
        
            Anmelder/Inhaber
            
        
 
        
            weitere Inhaber
            
        
 
        
            Anmeldeland
            
        
 
        
            Priorität
            
        
 
    
        Begutachtungsstatus
        Peer reviewed
    
 
     
    
        POF Topic(s)
        30205 - Bioengineering and Digital Health
    
 
    
        Forschungsfeld(er)
        Enabling and Novel Technologies
    
 
    
        PSP-Element(e)
        G-505500-001
    
 
    
        Förderungen
        
    
 
    
        Copyright
        
    
 	
    
    
        Erfassungsdatum
        2011-12-31