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Fuchs, H. ; Gailus-Durner, V. ; Adler, T.* ; Aguilar-Pimentel, J.A.* ; Becker, L.* ; Calzada-Wack, J. ; Da Silva-Buttkus, P. ; Neff, F. ; Götz, A.A. ; Hans, W. ; Hölter, S.M. ; Horsch, M. ; Kastenmüller, G. ; Kemter, E.* ; Lengger, C. ; Maier, H. ; Matloka, M. ; Möller, G. ; Naton, B. ; Prehn, C. ; Puk, O. ; Rácz, I.* ; Rathkolb, B.* ; Römisch-Margl, W. ; Rozman, J. ; Wang-Sattler, R. ; Schrewe, A.* ; Stoeger, C. ; Tost, M. ; Adamski, J. ; Aigner, B.* ; Beckers, J. ; Behrendt, H. ; Busch, D.H.* ; Esposito, I. ; Graw, J. ; Illig, T. ; Ivandic, B.* ; Klingenspor, M.* ; Klopstock, T.* ; Kremmer, E. ; Mempel, M.* ; Neschen, S. ; Ollert, M.* ; Schulz, S. ; Suhre, K. ; Wolf, E.* ; Wurst, W. ; Zimmer, A.* ; Hrabě de Angelis, M.

Mouse phenotyping.

Methods 53, 120-135 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Model organisms like the mouse are important tools to learn more about gene function in man. Within the last 20years many mutant mouse lines have been generated by different methods such as ENU mutagenesis, constitutive and conditional knock-out approaches, knock-down, introduction of human genes, and knock-in techniques, thus creating models which mimic human conditions. Due to pleiotropic effects, one gene may have different functions in different organ systems or time points during development. Therefore mutant mouse lines have to be phenotyped comprehensively in a highly standardized manner to enable the detection of phenotypes which might otherwise remain hidden. The German Mouse Clinic (GMC) has been established at the Helmholtz Zentrum München as a phenotyping platform with open access to the scientific community (www.mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2]).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Mouse phenotyping
Sprache englisch
Veröffentlichungsjahr 2011
Prepublished im Jahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 1046-2023
e-ISSN 1095-9130
Zeitschrift Methods
Quellenangaben Band: 53, Heft: 2, Seiten: 120-135 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Pathology (PATH)
Institute of Lung Health and Immunity (LHI)
Institute of Developmental Genetics (IDG)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Institute of Molecular Immunology (IMI)
POF Topic(s) 30201 - Metabolic Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
30204 - Cell Programming and Repair
30505 - New Technologies for Biomedical Discoveries
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
Enabling and Novel Technologies
Lung Research
PSP-Element(e) G-500600-003
G-500600-001
G-500600-004
G-505600-001
G-500300-001
G-505000-004
G-500500-001
G-500500-002
G-503700-001
G-503900-003
G-501700-003
G-521200-001
FE 73991
G-503900-001
PubMed ID 20708688
DOI 10.1016/j.ymeth.2010.08.006
WOS ID WOS:000287275900003
Scopus ID 79251597943
Erfassungsdatum 2010-12-31
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