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Fuchs, H. ; Gailus-Durner, V. ; Adler, T.* ; Aguilar-Pimentel, J.A.* ; Becker, L.* ; Calzada-Wack, J. ; Da Silva-Buttkus, P. ; Neff, F. ; Götz, A.A. ; Hans, W. ; Hölter, S.M. ; Horsch, M. ; Kastenmüller, G. ; Kemter, E.* ; Lengger, C. ; Maier, H. ; Matloka, M. ; Möller, G. ; Naton, B. ; Prehn, C. ; Puk, O. ; Rácz, I.* ; Rathkolb, B.* ; Römisch-Margl, W. ; Rozman, J. ; Wang-Sattler, R. ; Schrewe, A.* ; Stoeger, C. ; Tost, M. ; Adamski, J. ; Aigner, B.* ; Beckers, J. ; Behrendt, H. ; Busch, D.H.* ; Esposito, I. ; Graw, J. ; Illig, T. ; Ivandic, B.* ; Klingenspor, M.* ; Klopstock, T.* ; Kremmer, E. ; Mempel, M.* ; Neschen, S. ; Ollert, M.* ; Schulz, S. ; Suhre, K. ; Wolf, E.* ; Wurst, W. ; Zimmer, A.* ; Hrabě de Angelis, M.

Mouse phenotyping.

Methods 53, 120-135 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Model organisms like the mouse are important tools to learn more about gene function in man. Within the last 20years many mutant mouse lines have been generated by different methods such as ENU mutagenesis, constitutive and conditional knock-out approaches, knock-down, introduction of human genes, and knock-in techniques, thus creating models which mimic human conditions. Due to pleiotropic effects, one gene may have different functions in different organ systems or time points during development. Therefore mutant mouse lines have to be phenotyped comprehensively in a highly standardized manner to enable the detection of phenotypes which might otherwise remain hidden. The German Mouse Clinic (GMC) has been established at the Helmholtz Zentrum München as a phenotyping platform with open access to the scientific community (www.mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2]).
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Mouse phenotyping
ISSN (print) / ISBN 1046-2023
e-ISSN 1095-9130
Zeitschrift Methods
Quellenangaben Band: 53, Heft: 2, Seiten: 120-135 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Pathology (PATH)
Institute of Lung Biology (LHI)
Institute of Developmental Genetics (IDG)
Institute of Bioinformatics and Systems Biology (IBIS)
Institute of Epidemiology (EPI)
Institute of Molecular Immunology (IMI)
CCG Environmental Dermatology and Allergology (ILBD-KAU)
Institute of Epidemiology (EPI)