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Albert, M.H.* ; Mannert, J.* ; Fleischmann, K.K.* ; Schiemann, M. ; Pagel, P.* ; Schmid, I.* ; Magg, T.*

MiRNome and transcriptome aided pathway analysis in human regulatory T cells.

Genes Immun. 15, 303-312 (2014)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Owing to their manifold immune regulatory functions, regulatory T cells (Treg) have received tremendous interest as targets for therapeutic intervention of diverse immunological pathologies or cancer. Directed manipulation of Treg will only be achievable with extensive knowledge about the intrinsic programs that define their regulatory function. We simultaneously analyzed miR and mRNA transcript levels in resting and activated human Treg cells in comparison with non-regulatory conventional T cells (Tcon). Based on experimentally validated miR-target information, both transcript levels were integrated into a comprehensive pathway analysis. This strategy revealed characteristic signal transduction pathways involved in Treg biology such as T-cell receptor-, Toll-like receptor-, transforming growth factor-β-, JAK/STAT (Janus kinase/signal transducers and activators of transcription)- and mammalian target of rapamycin signaling, and allowed for the prediction of specific pathway activities on the basis of miR and mRNA transcript levels in a probabilistic manner. These data encourage new concepts for targeted control of Treg cell effector functions.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Foxp3 Target Genes; Nf-kappa-b; Immune-responses; Th1 Responses; Expression; Microrna; Induction; Differentiation; Smad3; Lists
Sprache
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1466-4879
e-ISSN 1476-5470
Zeitschrift Genes and Immunity
Quellenangaben Band: 15, Heft: 5, Seiten: 303-312 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501790-003
DOI 10.1038/gene.2014.20
WOS ID WOS:000339537900005
Scopus ID 84905055176
Scopus ID 84900778483
PubMed ID 24848933
Erfassungsdatum 2014-05-24
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