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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Genetic risk models in age-related macular degeneration.
Adv. Exp. Med. Biol. 801, 291-300 (2014)
Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Herausgeber
Ash, J.D.* ; Grimm, C.* ; Hollyfield, J.G.* ; Anderson, R.E.* ; LaVail, M.M.* ; Bowes Rickman, C.*
Schlagwörter
Age-related macular degeneration ; Susceptibility ; Logistic regression ; Cox regression ; Genetic risk score; Clinical-trial; United-states; Prevalence; Cfh; Progression; Severity; C2
ISSN (print) / ISBN
0065-2598
ISBN
978-1-4614-3208-1
Konferenztitel
Retinal Degenerative Diseases : Mechanisms and Experimental Therapy
Zeitschrift
Advances in Experimental Medicine and Biology
Quellenangaben
Band: 801,
Seiten: 291-300
Reihe
Retinal Degenerative Diseases
Verlag
Springer
Verlagsort
New York
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Genetic Epidemiology (IGE)