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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Attentional impulsivity in binge eating disorder modulates response inhibition performance and frontal brain networks.
Int. J. Obes. 39, 353-360 (2015)
Background:A subgroup of overweight and obese people is characterized by binge eating disorder (BED). Increased impulsivity has been suggested to cause binge eating and subsequent weight gain. In the current study, neuronal correlates of increased impulsivity in binge eating disorder during behavioral response inhibition were investigated.Methods:Magnetic brain activity and behavioral responses of 37 overweight and obese individuals with and without diagnosed binge eating disorder were recorded while performing a food-related visual go-nogo task. Trait impulsivity was assessed with the Barratt Impulsiveness Scale (BIS-11).Results:Specifically increased attentional impulsiveness (a subscale of the BIS-11) in BED was related to decreased response inhibition performance and hypoactivity in the prefrontal control network which was activated when response inhibition was required. Furthermore, participants with BED showed a trend for a food specific inhibition performance decline. This was possibly related to the absence of a food specific activity increase in the prefrontal control network in BED, as observed in the control group. In addition, an increase in activity related to the actual button press during prepotent responses and alterations in visual processing were observed.Conclusions:Our results suggest an attentional impulsiveness related attenuation in response inhibition performance in individuals with BED. This might have been related to increased reward responsiveness and limited resources to activate the prefrontal control network involved in response inhibition. Our results substantiate the importance of neuronal markers for investigating prevention and treatment of obesity especially in specific subgroups at risk like BED.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Obesity; Task; Activation; Scale; Fmri; Food; Associations; Metaanalysis; Comorbidity; Prevalence
ISSN (print) / ISBN
0307-0565
e-ISSN
1476-5497
Zeitschrift
International Journal of Obesity
Quellenangaben
Band: 39,
Heft: 2,
Seiten: 353-360
Verlag
Nature Publishing Group
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed