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Multhoff, G. ; Radons, J.R.* ; Vaupel, P.W.*

Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance.

Cancers 6, 813-823 (2014)
Verlagsversion Volltext DOI
Open Access Gold
Creative Commons Lizenzvertrag
Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Hypoxia Modifiers ; Hypoxia-inducible Factor (hif) ; Radioresistance ; Tumor Angiogenesis ; Tumor Hypoxia ; Tumor Microcirculation
ISSN (print) / ISBN 2072-6694
Zeitschrift Cancers
Quellenangaben Band: 6, Heft: 2, Seiten: 813-823 Artikelnummer: , Supplement: ,
Verlag MDPI
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)