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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Impaired NK cells and increased T regulatory cell numbers during cytotoxic maintenance therapy in AML.
Leuk. Res. 38, 964-969 (2014)
Cyclic cytotoxic maintenance therapy can be applied to patients with AML in post-remission. We studied the immune status of AML patients in complete remission and the effect of maintenance therapy on different immune cell populations. Patients in complete remission had reduced NK, TH and Treg counts and a reduced NK activation capacity. In the course of cytotoxic maintenance therapy, NK counts further declined, while TH and Treg cells increased, with lower proliferative potential of TH cells. We conclude that immunotherapeutic approaches in post-remission have to consider reduced NK cell function and further impairment of cellular immune responses during cytotoxic therapy.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Acute Myeloid Leukemia ; Cytotoxic Therapy ; Immunomonitoring ; Maintenance Therapy ; Nk Cell ; T Regulatory Cell
ISSN (print) / ISBN
0145-2126
e-ISSN
1873-5835
Zeitschrift
Leukemia Research
Quellenangaben
Band: 38,
Heft: 8,
Seiten: 964-969
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Hematopoetic Cell Transplants (IMI-KHZ)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)