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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
House dust-mite allergen exposure is associated with serum specific IgE but not with respiratory outcomes.
Indoor Air 25, 235-244 (2015)
Exposure to house dust has been associated with asthma in adults, and this is commonly interpreted as a direct immunologic response to dust-mite allergens in those who are IgE sensitized to house dust-mite. Mattress house dust-mite concentrations were measured in a population-based sample of 2890 adults aged between 27 and 56 years living in 22 centers in 10 countries. Generalized linear mixed models were employed to explore the association of respiratory symptoms with house dust-mite concentrations, adjusting for individual and household confounders. There was no overall association of respiratory outcomes with measured house dust-mite concentrations, even in those who reported they had symptoms on exposure to dust and those who had physician-diagnosed asthma. However, there was a positive association of high serum specific IgE levels to HDM (>3.5 kUA/l) with mattress house dust-mite concentrations and a negative association of sensitization to cat with increasing house dust-mite concentrations. In conclusion, there was no evidence that respiratory symptoms in adults were associated with exposure to house dust-mite allergen in the mattress, but an association of house mite with strong sensitization was observed. © 2014 John Wiley & Sons A/S.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Asthma ; Ecrhs ; House Dust-mite Concentrations ; Lung Function; Health Survey-ii; Bronchial Responsiveness; Childhood Asthma; Cat Allergens; Children; Homes; Sensitization; Metaanalysis; Community; Sample
ISSN (print) / ISBN
0905-6947
e-ISSN
1600-0668
Zeitschrift
Indoor Air
Quellenangaben
Band: 25,
Heft: 3,
Seiten: 235-244
Verlag
Wiley
Verlagsort
Hoboken
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Epidemiology (EPI)