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Ehninger, D.* ; Neff, F. ; Xie, K.*

Longevity, aging and rapamycin.

Cell. Mol. Life Sci. 71, 4325-4346 (2014)
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Open Access Gold
Creative Commons Lizenzvertrag
The federal drug administration (FDA)-approved compound rapamycin was the first pharmacological agent shown to extend maximal lifespan in both genders in a mammalian species. A major question then is whether the drug slows mammalian aging or if it has isolated effects on longevity by suppressing cancers, the main cause of death in many mouse strains. Here, we review what is currently known about the effects that pharmacological or genetic mammalian target of rapamycin (mTOR) inhibition have on mammalian aging and longevity. Currently available evidence seems to best fit a model, wherein rapamycin extends lifespan by suppressing cancers. In addition the drug has symptomatic effects on some aging traits, such as age-related cognitive impairments.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Aging ; Anti-aging ; Cancer ; Cardiovascular Disease ; Disease ; Drug ; Lifespan ; Longevity ; Mammalian Target Of Rapamycin ; Mammals ; Mechanism ; Mice ; Mtor ; Neurodegeneration ; Prevention ; Rapamycin ; Treatment
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1420-682X
e-ISSN 1420-9071
Zeitschrift Cellular and Molecular Life Sciences - CMLS
Quellenangaben Band: 71, Heft: 22, Seiten: 4325-4346 Artikelnummer: , Supplement: ,
Verlag Birkhäuser
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pathology (PATH)
Institute of Experimental Genetics (IEG)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30201 - Metabolic Health
Forschungsfeld(er) Enabling and Novel Technologies
Genetics and Epidemiology
PSP-Element(e) G-500300-001
G-500600-001
DOI 10.1007/s00018-014-1677-1
WOS ID WOS:000344596900002
Scopus ID 84903859182
Erfassungsdatum 2014-07-23
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