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Jansen, R.P.* ; Niessing, D. ; Baumann, S.* ; Feldbrügge, M.*

MRNA transport meets membrane traffic.

Trends Genet. 30, 408-417 (2014)
Verlagsversion DOI PMC
Active transport and local translation of mRNAs ensure the appropriate spatial organization of proteins within cells. Recent work has shown that this process is intricately connected to membrane trafficking. Here, we focus on new findings obtained in fungal model systems. Important highlights are that RNA-binding proteins recognize cargo mRNA synergistically and that mRNAs are co-transported with membranous compartments such as the endoplasmic reticulum (ER) and endosomes. We further discuss a novel concept of endosome-coupled translation that loads shuttling endosomes with septin cargo, a process important for correct septin filamentation. Interestingly, evidence is accumulating that RNA and membrane trafficking are also tightly interwoven in higher eukaryotes, suggesting that this phenomenon is a common theme and not an exception restricted to fungi.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Actin ; Endoplasmic Reticulum ; Endosomes ; Microtubule ; Mrnp ; Septin
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 0168-9479
Zeitschrift Trends in Genetics
Quellenangaben Band: 30, Heft: 9, Seiten: 408-417 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Structural Biology (STB)
POF Topic(s) 30203 - Molecular Targets and Therapies
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503091-001
PubMed ID 25110341
DOI 10.1016/j.tig.2014.07.002
WOS ID WOS:000342036000004
Scopus ID 85027943292
Erfassungsdatum 2014-08-13
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