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Hoene, M.* ; Li, J.* ; Häring, H.-U. ; Weigert, C. ; Xu, G.* ; Lehmann, R.

The lipid profile of brown adipose tissue is sex-specific in mice.

Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1841, 1563-1570 (2014)
Preprint DOI PMC
Creative Commons Lizenzvertrag
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Brown adipose tissue (BAT) is a thermogenic organ with a vital function in small mammals and potential as metabolic drug target in humans. By using high-resolution LC-tandem-mass spectrometry, we quantified 329 lipid species from 17 (sub)classes and identified the fatty acid composition of all phospholipids from BAT and subcutaneous and gonadal white adipose tissue (WAT) from female and male mice. Phospholipids and free fatty acids were higher in BAT, while DAG and TAG levels were higher in WAT. A set of phospholipids dominated by the residue docosahexaenoic acid, which influences membrane fluidity, showed the highest specificity for BAT. We additionally detected major sex-specific differences between the BAT lipid profiles, while samples from the different WAT depots were comparatively similar. Female BAT contained less triacylglycerol and more phospholipids rich in arachidonic and stearic acid whereas another set of fatty acid residues that included linoleic and palmitic acid prevailed in males. These differences in phospholipid fatty acid composition could greatly affect mitochondrial membranes and other cellular organelles and thereby regulate the function of BAT in a sex-specific manner.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Bat ; Wat ; Brown Adipose Tissue ; Female And Male Mice ; Gonadal Fat ; Phospholipids ; Sex-specific Difference ; Subcutaneous Fat ; Tandem-ms Lipidomics ; White Adipose Tissue
ISSN (print) / ISBN 1388-1981
Zeitschrift Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Quellenangaben Band: 1841, Heft: 10, Seiten: 1563-1570 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Experimental Genetics (IEG)