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Liu, C. ; Fuertes, E. ; Flexeder, C. ; Hofbauer, L.C.* ; Berdel, D.* ; Hoffmann, B.H.* ; Kratzsch, J.K.* ; von Berg, A.* ; Heinrich, J. ; GINIplus Study Group (Chen, C.M. ; Filipiak, B. ; Franke, K. ; Gehring, U. ; Laubereau, B. ; Popescu, M. ; Sausenthaler, S. ; Schoetzau, A. ; Wichmann, H.-E. ; Zutavern, A.) ; LISAplus Study Group (Schnappinger, M.)

Associations between ambient air pollution and bone turnover markers in 10-year old children: Results from the GINIplus and LISAplus studies.

Int. J. Hyg. Environ. Health 218, 58-65 (2015)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Negative associations between bone turnover markers and bone mineral density have been reported. In order to study the association between ambient air pollution and bone turnover markers, as indicators of bone loss, we investigated associations between land-use regression modeled air pollution (NO2, PM2.5 mass, PM2.5 - 10 [coarse particles], PM10 mass and PM2.5 absorbance) and bone turnover markers in 2264 children aged 10 years. Serum osteocalcin and C-terminal telopeptide of type I collagen (CTx), measured by Modular-System (Roche), were the two bone turnover markers considered in this analysis. In total population, NO2, PM2.5 - 10 and PM10 mass exposure were positively and significantly associated with both osteocalcin and CTx. A 2.5 (95% CI: 0.6, 4.4) ng/ml increase in osteocalcin and a 24.0 (95% CI: 6.7, 41.3) ng/L increase in CTx were observed per IQR (6.7 μg/m3) increase in NO2, independent of socioeconomic status, sex, age, pubertal status, fasting status and total physical activity. The estimated coefficients were 3.0 (95% CI: 0.1, 5.8) for osteocalcin and 32.3 (95% CI: 6.1, 58.5) for CTx with PM2.5 - 10; 3.2 (95% CI: 0.0, 6.4) for osteocalcin and 30.7 (95% CI: 1.7, 59.7) for CTx with PM10. Children living close to a major road (≤ 350 m) had higher levels of both osteocalcin (1.4 [-1.2, 4.0] ng/ml) and CTx (16.2 [-7.4, 39.8] ng/L). The adverse impact of ambient air pollution on bone turnover rates observed in one of the study areas showed stimulation of more such studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Ambient Air Pollution ; Bone Health ; Bone Turnover Markers ; Children ; Epidemiology; Use Regression-models; Mineral Density; Biochemical Markers; Escape Project; Elderly-men; Serum Osteocalcin; Pm2.5 Absorbency; Cortical Bone; Birth Cohort; Areas
Sprache englisch
Veröffentlichungsjahr 2015
Prepublished im Jahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1438-4639
e-ISSN 1618-131X
Zeitschrift International Journal of Hygiene and Environmental Health
Quellenangaben Band: 218, Heft: 1, Seiten: 58-65 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam ; Boston, Mass. ; London ; New York, NY ; Oxford ; Paris ; Philadelphia, Pa. ; San Diego, Calif. ; St. Louis, Mo. ; München
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
G-503900-003
PubMed ID 25153026
DOI 10.1016/j.ijheh.2014.07.006
WOS ID WOS:000347661800008
Scopus ID 84927691997
Scopus ID 84905888428
Erfassungsdatum 2014-08-22
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