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    Uroguanylin: How the gut got another satiety hormone.
        
        J. Clin. Invest. 121, 3384-3386 (2011)
    
    
    
				Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI, Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS, which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity.
			
			
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        Publikationstyp
        Artikel: Journalartikel
    
 
    
        Dokumenttyp
        Wissenschaftlicher Artikel
    
 
     
    
     
     
    
    
        Sprache
        englisch
    
 
    
        Veröffentlichungsjahr
        2011
    
 
     
    
        HGF-Berichtsjahr
        0
    
 
    
    
        ISSN (print) / ISBN
        0021-9738
    
 
    
        e-ISSN
        1558-8238
    
 
     
     
     
	     
	 
	 
    
        Zeitschrift
        Journal of Clinical Investigation
    
 
		
    
        Quellenangaben
        
	    Band: 121,  
	    Heft: 9,  
	    Seiten: 3384-3386 
	    
	    
	
    
 
  
         
        
            Verlag
            American Society of Clinical Investigation
        
 
         
	
         
         
         
         
         
	
         
         
         
    
         
         
         
         
         
         
         
    
        Begutachtungsstatus
        Peer reviewed
    
 
    
        Institut(e)
        Institute of Diabetes and Obesity (IDO)
    
 
    
        POF Topic(s)
        30201 - Metabolic Health
    
 
    
        Forschungsfeld(er)
        Helmholtz Diabetes Center
    
 
    
        PSP-Element(e)
        G-502200-001
    
 
     
     	
    
        PubMed ID
        21865649
    
    
        DOI
        10.1172/JCI58297
    
    
        Erfassungsdatum
        2011-12-31