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Gross, C.* ; Holler, E.* ; Stangl, S. ; Dickinson, A.* ; Pockley, A.G. ; Asea, A.A.* ; Mallappa, N.* ; Multhoff, G.

An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.

Leuk. Res. 32, 527-537 (2008)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell transplantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Hsp70 peptide TKD; HLA-E; NK cells; Stem cell transplantation; Cytotoxicity
ISSN (print) / ISBN 0145-2126
e-ISSN 1873-5835
Zeitschrift Leukemia Research
Quellenangaben Band: 32, Heft: 4, Seiten: 527-537 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Innate Immunity in Tumor Biology (PATH-KTB)