Hinweise zu Qualitätskriterien von Zeitschriften
Open-Access-Richtlinie der Helmholtz-Gemeinschaft 2016
CC Licencences
Metriken für Publikationen
Startseite
Login
English
Neuer EVA Antrag
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
HGF Fortschrittsbericht
OA Publikationen
Neue Publikation eintragen
Neue Publikation holen aus...
Fehlende Publikation melden
Ansprechpartner
Hilfe
Bibliometrische Indikatoren
Text
Endnote (RIS)
BibTeX
DOI
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Immune mechanisms and development of childhood asthma.
Lancet Resp. Med. 2, 647-656 (2014)
Early life influences are crucial for the development of distinct childhood asthma phenotypes, which are currently included under the term asthma syndrome. Improved characterisation of different childhood asthma phenotypes will help to elucidate specific underlying immune mechanisms-namely, endotypes. Besides genetics, epigenetics and environmental factors have an effect on innate and adaptive immune regulatory networks. Crucial determining factors for complex immune regulation and barrier function include family history of atopy, respiratory infections, microbiome, and nutrition. Recent diagnostic approaches, including biomarkers, might offer a unique opportunity to improve definitions of asthma sub-phenotypes, prediction of outcome, and treatment options, by referring to the underlying pathophysiology. For prevention and patient-individualised medicine, a multifactorial approach incorporating deep phenotyping and mathematical models for analysis to extend our present knowledge is needed.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
9.629
2.868
34
41
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
T-regulatory Cells; Respiratory Syncytial Virus; Early-life; Gene-expression; Nlrp3 Inflammasome; Allergic Diseases; Dna Methylation; Airway Disease; Birth Cohort; Folic-acid
Sprache
englisch
Veröffentlichungsjahr
2014
HGF-Berichtsjahr
2015
ISSN (print) / ISBN
2213-2600
Zeitschrift
Lancet Respiratory Medicine, The
Quellenangaben
Band: 2,
Heft: 8,
Seiten: 647-656
Verlag
Elsevier
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Lung Health and Immunity (LHI)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Lung Research
PSP-Element(e)
G-501600-001
WOS ID
WOS:000340337300015
Erfassungsdatum
2015-01-01