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Enhanced H-bonding and π-stacking in DNA: A potent duplex-stabilizing and mismatch sensing nucleobase analogue.
Chem. Sci. 5, 3836-3844 (2014)
X-pyrene is a new nucleic acid duplex stabilizing cytosine analogue that combines enhanced π-stacking, hydrogen bonding and electrostatic interactions to greatly increase the stability of bulged DNA duplexes and DNA/RNA hybrids. X-pyrene is highly selective for guanine as a partner and duplex stability is reduced dramatically when X-pyrene or a neighboring base is mismatched. An NMR study indicates that the pyrene moiety stacks within the helix, and large changes in fluorescence emission on duplex formation are consistent with this. These favorable properties make X-pyrene a promising cytosine analogue for use in a variety of biological applications.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Nucleic-acids; G-clamp; Cytosine Analog; High-affinity; Base Analogs; Oligonucleotides; Pyrene; Rna; Fluorescence; Binding
ISSN (print) / ISBN
2041-6520
e-ISSN
2041-6539
Zeitschrift
Chemical Science
Quellenangaben
Band: 5,
Heft: 10,
Seiten: 3836-3844
Verlag
Royal Society of Chemistry (RSC)
Verlagsort
Cambridge
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Structural Biology (STB)