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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
A review of standardized metabolic phenotyping of animal models.
Mamm. Genome 25, 497-507 (2014)
Metabolic phenotyping of genetically modified animals aims to detect new candidate genes and related metabolic pathways that result in dysfunctional energy balance regulation and predispose for diseases such as obesity or type 2 diabetes mellitus. In this review, we provide a comprehensive overview on the technologies available to monitor energy flux (food uptake, bomb calorimetry of feces and food, and indirect calorimetry) and body composition (qNMR, DXA, and MRI) in animal models for human diseases with a special focus on phenotyping methods established in genetically engineered mice. We use an energy flux model to illustrate the principles of energy allocation, describe methodological aspects how to monitor energy balance, and introduce strategies for data analysis and presentation.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Indirect Calorimetry; Body-composition; Energy-intake; Magnetic-resonance; Insulin-resistance; Adipose-tissue; Mice; Obesity; Mouse; Diet
ISSN (print) / ISBN
0938-8990
e-ISSN
1432-1777
Zeitschrift
Mammalian Genome
Quellenangaben
Band: 25,
Heft: 9,
Seiten: 497-507
Verlag
Springer
Verlagsort
New York
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)