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Stigloher, C. ; Chapouton, P. ; Adolf, B. ; Bally-Cuif, L.

Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain.

Brain Res. Bull. 75, 266-273 (2008)
DOI
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
The maintenance of progenitor cells is a crucial aspect of central nervous system development and maturation, and bHLH transcription factors of the E(Spl) subfamily are involved in this process in all vertebrates studied to date. In the zebrafish embryonic neural plate, a large number of E(Spl) genes (her genes) are at play. We review recent data on this point, and propose a model where distinct subsets of these genes define different progenitor subtypes. Analysis of her genes expression in the adult zebrafish brain suggests that part of the embryonic her cascade might also be reused to define progenitors during adulthood. Further, available evidence on orthologous genes in the mouse (Hes genes) point to different modes of Hes regulation depending on cell location within the embryonic neural tube, perhaps associated with distinct progenitor types in this species as well. Out of these comparisons emerges a simple model of neural stem cell maintenance applicable from embryonic development until adulthood as well as across species. This working model suggests the directions for future experiments.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Neurogenesis; Neural stem cell; Neural progenitor; E(Spl); her; Hes
ISSN (print) / ISBN 0361-9230
e-ISSN 1873-2747
Zeitschrift Brain Research Bulletin
Quellenangaben Band: 75, Heft: 2-4, Seiten: 266-273 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)