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Rachner, T.D.* ; Thiele, S.* ; Goebel, A.* ; Browne, A.* ; Fuessel, S.* ; Erdmann, K.* ; Wirth, M.P.* ; Froehner, M.* ; Todenhoefer, T.* ; Muders, M.H.* ; Kieslinger, M. ; Rauner, M.* ; Hofbauer, L.C.*

High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients.

BMC Cancer 14:649 (2014)
Verlagsversion DOI
Open Access Gold
Creative Commons Lizenzvertrag
Background: The Wnt inhibitor Dickkopf-1 (DKK-1) has been linked to the progression of malignant bone disease by impairing osteoblast activity. In addition, there is increasing data to suggest direct tumor promoting effects of DKK-1. The prognostic role of DKK-1 expression in prostate cancer remains unclear. Methods: A prostate cancer tissue microarray (n = 400) was stained for DKK-1 and DKK-1 serum levels were measured in 80 patients with prostate cancer. The independent prognostic value of DKK-1 expression was assessed using multivariate analyses. Results: DKK-1 tissue expression was significantly increased in prostate cancer compared to benign disease, but was not correlated with survival. However, high DKK-1 serum levels at the time of the diagnosis were associated with a significantly shorter overall and disease-specific survival. Multivariate analyses defined high serum levels of DKK-1 as an independent prognostic marker in prostate cancer (HR 3.73; 95%CI 1.44-9.66, p = 0.007). Conclusion: High DKK-1 serum levels are associated with a poor survival in patients with prostate cancer. In light of current clinical trials evaluating the efficacy of anti-DKK-1 antibody therapies in multiple myeloma and solid malignancies, the measurement of DKK-1 in prostate cancer may gain clinical relevance.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Dkk 1 ; Prostate Cancer ; Prognosis; Multiple-myeloma; Bone; Expression; Dkk-1
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1471-2407
e-ISSN 1471-2407
Zeitschrift BMC Cancer
Quellenangaben Band: 14, Heft: 1, Seiten: , Artikelnummer: 649 Supplement: ,
Verlag BioMed Central
Verlagsort London
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Clinical Molecular Biology and Tumor Genetics (K.MOLBI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501400-001
DOI 10.1186/1471-2407-14-649
WOS ID WOS:000341656800001
Scopus ID 84907415671
Erfassungsdatum 2014-10-13
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