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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics.
Nanoscale 6, 13451-13456 (2014)
Therapeutic applications of gene silencing using siRNA have seen increasing interest over the past decade. The optimization of the delivery and biodistribution of siRNA using liposome-gold nanorod (AuNRs) nanoscale carriers can greatly benefit from adept imaging methods that can visualize the time-resolved delivery performance of such vectors. In this work, we describe the effect of AuNR length incorporated with liposomes and show their complexation with siRNA as a novel gene delivery vehicle. We demonstrate the application of multispectral optoacoustic tomography (MSOT) to longitudinally visualize the localisation of siRNA carrying liposome-AuNR hybrids within tumors. Combination of in vivo MSOT with ex vivo fluorescence cryo-slice imaging offers further insight into the siRNA transport and activity obtained.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
2040-3364
e-ISSN
2040-3372
Zeitschrift
Nanoscale
Quellenangaben
Band: 6,
Heft: 22,
Seiten: 13451-13456
Verlag
Royal Society of Chemistry (RSC)
Verlagsort
Cambridge
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed