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Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
The CALM and CALM/AF10 interactor CATS is a marker for proliferation.
Mol. Oncol. 2, 356-367 (2008)
The CATS protein was recently identified as a novel CALM interacting protein. CATS increases the nuclear and specifically the nucleolar localization of the leukemogenic CALM/AF10 fusion protein. We cloned and characterized the murine Cats gene. Detailed analysis of murine Cats expression during mouse embryogenesis showed an association with rapidly proliferating tissues. Interestingly, the Cats transcript is highly expressed in murine hematopoietic cells transformed by CALM/AF10. The CATS protein is highly expressed in leukemia, lymphoma and tumor cell lines but not in non-proliferating T-cells or human peripheral blood lymphocytes. CATS protein levels are cell cycle dependent and it is induced by mitogens, suggesting a role of CATS in the control of cell proliferation and possibly CALM/AF10-mediated leukemogenesis.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
CALM/AF10; Leukemia; Nucleolus; Proliferation; CATS
ISSN (print) / ISBN
1574-7891
e-ISSN
1878-0261
Zeitschrift
Molecular Oncology
Quellenangaben
Band: 2,
Heft: 4,
Seiten: 356-367
Verlag
Elsevier
Verlagsort
Amsterdam [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed