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Rittner, C.K.* ; Opferkuch, W.* ; Wellek, B.* ; Grosse-Wilde, H. ; Wernet, P.A.*

Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man.

Hum. Genet. 34, 137-142 (1976)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygousdeficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HLA-A,B antigens, HLA-D (MLC) determinants; the Bf system; glyoxalase I and B cell antigens. No evidence for linkage between the immunogenetic linkage group on chromosome 6 and gene(s) controlling the synthesis of the seventh component of complement was obtained. This is in accordance with the assumption that only genes controlling components of the initiating rather than the membrane attack unit of complement are linked to the HLA region.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 0340-6717
e-ISSN 1432-1203
Zeitschrift Human Genetics
Quellenangaben Band: 34, Heft: 2, Seiten: 137-142 Artikelnummer: , Supplement: ,
Verlag Springer
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed