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Distribution of s1-nuclease sensitive sites and double-Strand breaks in γ-irradiated λ-DNA.
Int. J. Radiat. Biol. 46, 675-679 (1984)
Double-strand breaks and regions with unpaired bases (S1-nuclease sensitive sites) are formed in the DNA of γirradiated λphages. The frequency of both events was determined in the various fragments produced after digestion with a restriction enzyme (Eco RI). The results show that both types of radiation damage are randomly distributed in the DNA molecule. There is no hint that the S1 sites are formed in preferred regions of the λgenome.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Base Damage ; Double-strand Breaks ; S1-nuclease ; λphage
ISSN (print) / ISBN
0955-3002
e-ISSN
1362-3095
Zeitschrift
International Journal of Radiation Biology
Quellenangaben
Band: 46,
Heft: 6,
Seiten: 675-679
Verlag
Informa Healthcare
Begutachtungsstatus
Peer reviewed
Institut(e)
Abteilung für Strahlenbiologie und Biophysik