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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Relationship of body weight to disposition of hexachlorobenzene in rats.
Toxicol. Lett. 18, 171-175 (1983)
Male rats of various body weights were dosed twice with [14C]hexachlorobenzene (50 mg/kg, p.o.) in olive oil by gavage on 2 consecutive days. During 2 weeks after dosage, cumulative excretion into urine was about 1% of the dose and unrelated to body weight. Cumulative excretion into feces was 30 ± 10% of the dose and decreased with increasing body weight. In contrast, the concentration of hexachlorobenzene in urine, feces, kidney, liver and adipose tissue 14 days after dosing was higher in larger than in smaller animals. However, the relative concentration, i.e. the concentration of hexachlorobenzene in urine, feces or tissue divided by the concentration of hexachlorobenzene in adipose tissue, eliminated most of the variability among individual animals. This allows direct comparison of dispositional data of animals with greatly differing body burdens.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0378-4274
e-ISSN
1879-3169
Zeitschrift
Toxicology Letters
Quellenangaben
Band: 18,
Heft: 1-2,
Seiten: 171-175
Verlag
Elsevier
Verlagsort
Amsterdam
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed