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Winkelmann, J. ; Polo, O.* ; Provini, F.* ; Nevsimalova, S.* ; Kemlink, D.* ; Sonka, K.* ; Högl, B.* ; Poewe, W.* ; Stiasny-Kolster, K.* ; Oertel, W.* ; de Weerd, A.* ; Strambi, L.F.* ; Zucconi, M.* ; Pramstaller, P.P.* ; Arnulf, I.* ; Trenkwalder, C.* ; Klein, C.* ; Hadjigeorgiou, G.M.* ; Happe, S.* ; Rye, D.* ; Montagna, P.*

Genetics of restless legs syndrome (RLS: State-of-the-art and future directions).

Mov. Disord. 22, (Suppl.18), 449-458 (2007)
DOI
Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter restless legs syndrome; genetics; sleep
ISSN (print) / ISBN 0885-3185
e-ISSN 1531-8257
Zeitschrift Movement Disorders
Quellenangaben Band: 22, Heft: SUPPL. 18, Seiten: 449-458, Artikelnummer: , Supplement: (Suppl.18)
Verlag Wiley
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)