Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cellular target genes of Epstein-Barr virus nuclear antigen 2.
J. Virol. 80, 9761-9771 (2006)
Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order to identify cellular target genes that respond to EBNA-2 in the absence of other viral factors, we have performed a comprehensive search for EBNA-2 target genes in two EBV-negative B-cell lines. This screen identified 311 EBNA-2-induced and 239 EBNA-2-repressed genes that were significantly regulated in either one or both cell lines. The activation of most of these genes had not previously been attributed to EBNA-2 function and will be relevant for the identification of EBNA-2-specific contributions to EBV-associated malignancies. The diverse spectrum of EBNA-2 target genes described in this study reflects the broad spectrum of EBNA-2 functions involved in virus-host interactions, including cell signaling molecules, adapters, genes involved in cell cycle regulation, and chemokines. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
5.178
0.000
41
53
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2006
HGF-Berichtsjahr
2006
ISSN (print) / ISBN
0022-538X
e-ISSN
1098-5514
Zeitschrift
Journal of Virology
Quellenangaben
Band: 80,
Heft: 19,
Seiten: 9761-9771
Verlag
American Society for Microbiology (ASM)
Begutachtungsstatus
Peer reviewed
Institut(e)
Research Unit Gene Vector (AGV)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-501500-002
PubMed ID
16973580
Scopus ID
33748947532
Erfassungsdatum
2006-09-26