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Janzen, T. ; Giussani, A. ; Canzi, C. ; Gerundini, P.* ; Oeh, U. ; Hoeschen, C.

Investigation of biokinetics of radioiodine with a population kinetics approach.

Radiat. Prot. Dosim. 139, 232-235 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The dosimetric studies required for planning individually tailored radioiodine therapy of benign thyroid pathologies may be too complex and time-demanding for many ordinary nuclear medicine departments. In this work, a preliminary population kinetics approach was applied to a model structure for iodine biokinetics in order to identify those model features that actually need to be individually investigated, in order to simplify the protocol for data collection in patients. Data from 29 patients undergoing radioiodine therapy for the treatment of the autonomous nodule syndrome were used in the analysis. The greatest inter-individual variations were observed in the parameters describing the transformation of iodide into organic iodine in the thyroid and in the kinetics of the organic form.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Autonomous throid-nodule; Therapy; Dosimetry
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Zeitschrift Radiation Protection Dosimetry
Quellenangaben Band: 139, Heft: 1-3, Seiten: 232-235 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Research Unit Medical Radiation Physics and Diagnostics (AMSD)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-503600-001
G-503600-002
DOI 10.1093/rpd/ncq054
Scopus ID 77953355839
PubMed ID 20172932
Erfassungsdatum 2010-06-09
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