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Investigation of biokinetics of radioiodine with a population kinetics approach.
Radiat. Prot. Dosim. 139, 232-235 (2010)
The dosimetric studies required for planning individually tailored radioiodine therapy of benign thyroid pathologies may be too complex and time-demanding for many ordinary nuclear medicine departments. In this work, a preliminary population kinetics approach was applied to a model structure for iodine biokinetics in order to identify those model features that actually need to be individually investigated, in order to simplify the protocol for data collection in patients. Data from 29 patients undergoing radioiodine therapy for the treatment of the autonomous nodule syndrome were used in the analysis. The greatest inter-individual variations were observed in the parameters describing the transformation of iodide into organic iodine in the thyroid and in the kinetics of the organic form.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Autonomous throid-nodule; Therapy; Dosimetry
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 139,
Heft: 1-3,
Seiten: 232-235
Verlag
Oxford University Press
Verlagsort
Oxford
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed