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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Promotion of initiated cells by radiation-induced cell inactivation.
Radiat. Res. 170, 613-617 (2008)
Cells on the way to carcinogenesis can have a growth advantage relative to normal cells. It has been hypothesized that a radiation-induced growth advantage of these initiated cells might be induced by an increased cell replacement probability of initiated cells after inactivation of neighboring cells by radiation. Here Monte Carlo simulations extend this hypothesis for larger clones: The effective clonal expansion rate decreases with clone size. This effect is stronger for the two-dimensional than for the three-dimensional situation. The clones are irregular, far from a circular shape. An exposure-rate dependence of the effective clonal expansion rate could come in part from a minimal recovery time of the initiated cells for symmetric cell division.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
0033-7587
e-ISSN
1938-5404
Zeitschrift
Radiation Research
Quellenangaben
Band: 170,
Heft: 5,
Seiten: 613-617
Verlag
Radiation Research Society
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)