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Zeggini, E.* ; Scott, L.J.* ; Saxena, R.* ; Voight, B.F.* ; Marchini, J.L.* ; Hu, T.* ; de, Bakker, P.I.* ; Abecasis, G.R.* ; Almgren, P.* ; Andersen, G.* ; Ardlie, K.* ; Boström, K.B.* ; Bergman, R.N.* ; Bonnycastle, L.L.* ; Borch-Johnsen, K.* ; Burtt, N.P.* ; Chen, H.* ; Chines, P.S.* ; Daly, M.J.* ; Deodhar, P.* ; Ding, C.J.* ; Doney, A.S.* ; Duren, W.L.* ; Elliott, K.S.* ; Erdos, M.R.* ; Frayling, T.M.* ; Freathy, R.M.* ; Gianniny, L.* ; Grallert, H. ; Grarup, N.* ; Groves, C.J.* ; Guiducci, C.* ; Hansen, T.* ; Herder, C.* ; Hitman, G.A.* ; Hughes, T.E.* ; Isomaa, B.* ; Jackson, A.U.* ; Jørgensen, T.* ; Kong, A.* ; Kubalanza, K.* ; Kuruvilla, F.G.* ; Kuusisto, J.* ; Langenberg, C.* ; Lango, H.* ; Lauritzen, T.* ; Li, Y.* ; Lindgren, C.M.* ; Lyssenko, V.* ; Marvelle, A.F.* ; Meisinger, C. ; Midthjell, K.* ; Mohlke, K.L.* ; Morken, M.A.* ; Morris, A.D.* ; Narisu, N.* ; Nilsson, P.* ; Owen, K.R.* ; Palmer, C.N.* ; Payne, F.* ; Perry, J.R.* ; Pettersen, E.* ; Platou, C.* ; Prokopenko, I.* ; Qi, L.* ; Qin, L.* ; Rayner, N.W.* ; Rees, M.* ; Roix, J.J.* ; Sandbaek, A.* ; Shields, B.* ; Sjögren, M.* ; Steinthorsdottir, V.* ; Stringham, H.M.* ; Swift, A.J.* ; Thorleifsson, G.* ; Thorsteinsdottir, U.* ; Timpson, N.J.* ; Tuomi, T.* ; Tuomilehto, J.* ; Walker, M.* ; Watanabe, R.M.* ; Weedon, M.N.* ; Willer, C.J.* ; Wellcome Trust Case Consortium (WTCCC) (*) ; Illig, T. ; Hveem, K.* ; Hu, FB.* ; Laakso, M.* ; Stefansson, K.* ; Pedersen, O.* ; Wareham, N.J.* ; Barroso, I.* ; Hattersley, A.T.* ; Collins, FS.* ; Groop, L.* ; McCarthy, M.I.* ; Boehnke, M.* ; Altshuler, D.*

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

Nat. Genet. 40, 638-645 (2008)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 40, Heft: 5, Seiten: 638-645 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)