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Echtler, K.* ; Stark, K.* ; Lorenz, M.* ; Kerstan, S.* ; Walch, A.K. ; Jennen, L. ; Rudelius, M.* ; Seidl, S.* ; Kremmer, E. ; Emambokus, N.R.* ; von Bruehl, M.L.* ; Frampton, J.* ; Isermann, B.* ; Genzel-Boroviczény, O.* ; Schreiber, C.* ; Mehilli, J.* ; Kastrati, A.* ; Schwaiger, M.* ; Shivdasani, R.A.* ; Massberg, S.*

Platelets contribute to postnatal occlusion of the ductus arteriosus.

J. Nat. Med. 16, 75-82 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The ductus arteriosus (DA) is a fetal shunt vessel between the pulmonary artery and the aorta that closes promptly after birth. Failure of postnatal DA closure is a major cause of morbidity and mortality particularly in preterm neonates. The events leading to DA closure are incompletely understood. Here we show that platelets have an essential role in DA closure. Using intravital microscopy of neonatal mice, we observed that platelets are recruited to the luminal aspect of the DA during closure. DA closure is impaired in neonates with malfunctioning platelet adhesion or aggregation or with defective platelet biogenesis. Defective DA closure resulted in a left-to-right shunt with increased pulmonary perfusion, pulmonary vascular remodeling and right ventricular hypertrophy. Our findings indicate that platelets are crucial for DA closure by promoting thrombotic sealing of the constricted DA and by supporting luminal remodeling. A retrospective clinical study revealed that thrombocytopenia is an independent predictor for failure of DA closure in preterm human newborns, indicating that platelets are likely to contribute to DA closure in humans.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Nonsteroidal antiflammatory drugs; von-Willebrand-factor; Respiratory-distress syndrome; Acute myocardial-infarction; Permanent anatomic closure; Transcription factor NF-E2; IN-VIVO; Premature-infants; Nitric-oxide; Glycoprotein IIB
Sprache englisch
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 1340-3443
e-ISSN 1861-0293
Zeitschrift Journal of natural medicines
Quellenangaben Band: 16, Heft: 1, Seiten: 75-82 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Tokyo [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
Institute of Pathology (PATH)
Research Unit Analytical Pathology (AAP)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30205 - Bioengineering and Digital Health
Forschungsfeld(er)
Enabling and Novel Technologies
PSP-Element(e) G-501700-003
G-500300-001
G-500390-001
PubMed ID 19966813
DOI 10.1038/nm.2060
Scopus ID 73849131692
Erfassungsdatum 2010-03-19
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