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The mediator of RNA polymerase II.
Chromosoma 113, 399-408 (2005)
Mediator (TRAP/ARC/PC2) is a large (22–28 subunit) protein complex that binds RNA polymerase II and controls transcription from class II genes. The evolutionarily conserved core of Mediator is found in all eukaryotes. It binds RNA polymerase II and is probably critical for basal transcription but it also mediates activation and repression of transcription. During evolution the complex has acquired additional species-specific subunits. These serve as an interface for regulatory factors and support specific signalling pathways. Recent mechanistic studies are consistent with the hypothesis that Mediator marks genes for binding by RNA polymerase II whereupon it subsequently activates the preinitiation complex. It is further likely that Mediator coordinates the recruitment of chromatin-modifying cofactor activities.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
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Cited By
Cited By
Altmetric
2.714
0.000
64
65
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2005
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0009-5915
e-ISSN
1432-0886
Zeitschrift
Chromosoma
Quellenangaben
Band: 113,
Heft: 8,
Seiten: 399-408
Verlag
Springer
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Molecular Immunology (IMI)
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
FE 71781
Erfassungsdatum
2005-10-06