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Kohlhammer, Y. ; Raspe, H.* ; Marre, R.* ; Suttorp, N.* ; Welte, T.* ; Schäfer, T.*

Antibiotic treatment of community acquired pneumonia varies widely across Germany.

J. Infect. 54, 446-453 (2007)

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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.

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Community Acquired Pneumonia (CAP) is a frequent and potentially fatal infectious disease which, in the majority of cases, needs an antibiotic intervention.Objectives: Aim was to evaluate antibiotic treatment patterns regarding all types of mono- and combination-therapy throughout the local clinical centres (LCCs) represented in the German competence network CAPNETZ (= Community Acquired Pneumonia Network) and to identify clinical indicators for regional differences.Methods: We analysed outpatients and inpatients recruited between March 2003 and April 2005. Patient and treatment details were registered online using standardised data entry forms. A logistic regression model was issued for the 4 most frequently applied antibiotics, adjusting for potentially relevant confounders.Results: The study sample consisted of 3221 patients at the age of 18 to 102 years. Overall, aminopenicillins plus betalactamase inhibitor (20.4%), fluoroquinolone (17.0%), macrolides combined with cephalosporins third generation (10.6%) and cephalosporins third generation (8.9%) were most frequently prescribed. After control for potential confounders, significant treatment differences remained between study sites.

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