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Mocikat, R. ; Kardinal, C. ; Klobeck, H.-G.*

Differential interactions between the immunoglobulin heavy chain mu intron and 3' enhancer.

Eur. J. Immunol. 25, 3195-3198 (1995)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The immunoglobulin heavy chain 3' enhancer may be a novel type of a transcriptional regulation element in as much as its function is position dependent. We show that there are interactions between the mu intron and 3' enhancer which are differentially regulated depending on the distance between the two elements. Thus, a transcriptional repression is exerted by the 3' enhancer when juxtaposed to the intron enhancer. Whereas no or only modest synergism between the immunoglobulin mu intron and 3' enhancer has been reported to date, we show here that the stimulatory effect is substantially increased by extending the distance between the two enhancers. In our stable expression system, the mu intron enhancer insulated the test gene from neighboring chromatin.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Chimeric Antibody ; Enhancer ; Igh Locus ; Lymphoid Cell Line ; Transcriptional Regulation
ISSN (print) / ISBN 0014-2980
e-ISSN 1521-4141
Zeitschrift European Journal of Immunology
Quellenangaben Band: 25, Heft: 11, Seiten: 3195-3198 Artikelnummer: , Supplement: ,
Verlag Wiley
Verlagsort Hoboken
Begutachtungsstatus Peer reviewed
Institut(e) AG Translationale Molekulare Immunologie (TMI)