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Ziegler, A.-G.* ; Mollenhauer, U. ; Achenbach, P. ; Bonifacio, E.*

Anti-CCL3 autoantibodies are not markers of type 1 diabetes when measured by a commercial ELISA method.

Diabetologia 54, 699-700 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Autoantibodies are a hallmark feature of type 1 diabetes and have proved useful markers for disease prediction and classification [1]. New autoantibodies are of interest since they may strengthen disease relevance in autoantibody-positive individuals [2, 3]. Recently, autoantibodies against the inducible chemokine CCL3 were reported to be associated with type 1 diabetes [4], and commercial kits for the measurement of anti-CCL3 autoantibodies are now available. CCL3 is produced during inflammation and is suggested to be produced by beta cells under stress. We had the opportunity to evaluate this commercial kit and here report our findings. Sera from patients with new or recent onset of type 1 diabetes (n = 54; median age 10 years; IQR 7.5–13.5 years), controls (n = 40; median age 11.2 years; IQR 4.7–16.3 years), first-degree relatives of patients with type 1 diabetes (n = 33; median age 10.5 years; IQR 7.7–11.2 years) and participants with other autoimmune diseases (n = 17; median age 1
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Autoantibody; CCL3; ELISA; Type 1 diabetes
Sprache englisch
Veröffentlichungsjahr 2011
Prepublished im Jahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Zeitschrift Diabetologia
Quellenangaben Band: 54, Heft: 3, Seiten: 699-700 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin ; Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
Institute of Pancreatic Islet Research (IPI)
POF Topic(s) 30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-502100-001
PubMed ID 21127833
DOI 10.1007/s00125-010-1976-5
WOS ID 000286987000028
Scopus ID 79953760377
Erfassungsdatum 2010-12-03
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