PuSH - Publikationsserver des Helmholtz Zentrums München

Weber, L.W.D.* ; Palmer, C.D.* ; Rozman, K.K.

Reduced activity of tryptophan 2,3-dioxygenase in the liver of rats treated with chlorinated dibenzo-p-dioxins (CDDs): Dose-responses and structure-activity relationship.

Toxicology 86, 63-69 (1994)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The activity of tryptophan 2,3-dioxygenase (TdO) was measured in the livers of male Sprague-Dawley rats after acutely toxic doses (LD20-LD80) of chlorinated dibenzo-p-dioxins (CDDs) with 4 of the up to 7 chlorine substituents occupying the 2,3,7,8-positions. Treatment with toxic doses of CDDs results in voluntary feed refusal of rats. A corresponding involuntary reduction of feed intake in naive animals (pair-feeding) causes elevated levels of TdO activity. In the CDD treated rats, however, TdO activities were dose-dependently reduced. An LD80 reduced TdO activity to about 50% of the level found in the corresponding pair-fed animals. This decrease of TdO activity explains the dose-dependent increase of serum tryptophan, which in turn is the likely cause of voluntary feed refusal observed in CDD-treated rats. The activity of another enzyme which is regulated in a fashion very similar to that of TdO, viz., tyrosine aminotransferase (TAT), was consistently, but not dose-dependently, affected by treatment with CDDs.
Altmetric
Weitere Metriken?
[➜Einloggen]
Zusatzinfos bearbeiten [➜Einloggen]
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Chlorinated Dibenzo-p-dioxins ; Dose-response ; Structure-activity Relationship ; Tryptophan 2,3-dioxygenase ; Tyrosine Aminotransferase
ISSN (print) / ISBN 0300-483X
e-ISSN 0300-483X
Zeitschrift Toxicology
Quellenangaben Band: 86, Heft: 1-2, Seiten: 63-69 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed