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Eckardt-Schupp, F. ; Ahne, F.

Bridge-building between mathematical theory and molecular biology: The REV2 gene as paradigm.

Mutat. Res. -Fund. Mol. Mech. Mutag. 289, 39-46 (1993)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The DNA damage-repair theory of R.H. Haynes anticipated the possibility of doe-dependent repair processe. The mathematical formalism developed by Haynes and coworkers on the basis of this theory provided tools to probe for the existence of inducible components of mutation or recombination by analysis of dose-response curves. Subsequently, we found that biological and molecular analysis of the Saccharomyces cerevisiae REV2 gene supported the validity of the postulates derived from the mathematical analysis. In this particle, we briefly review the foregoing and summarize ebidence that the REV2 gene product might function in DNA damage-inducible repair and mutation processes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Damage-repair Theory ; Dna Damage-inducible Genes ; Mutation ; Repair
ISSN (print) / ISBN 0027-5107
e-ISSN 1873-135X
Zeitschrift Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis
Quellenangaben Band: 289, Heft: 1, Seiten: 39-46 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Biology (ISB)