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Lieb, W.* ; Mayer, B.* ; König, IR.* ; Borwitzky, I.* ; Götz, A.* ; Kain, S.* ; Hengstenberg, C.* ; Linsel-Nitschke, P.* ; Fischer, M.* ; Döring, A. ; Wichmann, H.-E. ; Meitinger, T. ; Kreutz, R.* ; Ziegler, A.* ; Schunkert, H.* ; Erdmann, J.*

Lack of association between the MEF2A gene and myocardial infarction.

Circulation 117, 185-191 (2008)
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Coronary artery disease (CAD) and myocardial infarction (MI) are caused in part by genetic factors. Recently, the MEF2A gene was linked to MI/CAD in a single pedigree with autosomal-dominant pattern of inheritance. In addition, genetic variants within the gene have been associated with MI in case-control settings, producing inconsistent results. METHODS AND RESULTS: The MEF2A gene was sequenced in MI patients from 23 MI families (> or =5 affected members per family), but no mutation was identified in any of these extended families. Moreover, the Pro279Leu variant in exon 7 was analyzed in 1181 unrelated MI patients with a positive family history for MI/CAD, in 533 patients with sporadic MI, and in 2 control populations (n=1021 and n=1055), showing no evidence for association with MI/CAD. In addition, a (CAG)n repeat in exon 11 was genotyped in 543 sporadic MI patients and in 1190 controls without evidence for association with MI. Finally, analyzing 11 single-nucleotide polymorphisms from the GeneChip Mapping 500K Array, genotyped in 1644 controls and 753 cases, failed to provide evidence for association (region-wide P=0.23). CONCLUSIONS: Studying independent samples of >1700 MI patients, 2 large control populations, and multiple families with apparently mendelian inheritance of the disease, we found no evidence for any linkage or association signal in the MEF2A gene.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter coronary disease; epidemiology; genetics; myocardial infarction
Sprache englisch
Veröffentlichungsjahr 2008
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0009-7322
e-ISSN 1524-4539
Zeitschrift Circulation
Quellenangaben Band: 117, Heft: 2, Seiten: 185-191 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Cooperation Group Comprehensive Molecular Analytics (CMA)
POF Topic(s)
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
Forschungsfeld(er)
Genetics and Epidemiology
Environmental Sciences
PSP-Element(e) G-503900-004
G-500700-001
G-504500-001
G-504000-002
PubMed ID 18086930
DOI 10.1161/CIRCULATIONAHA.107.728485
WOS ID 000252601400015
Erfassungsdatum 2008-04-04
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