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Kerler, F. ; Hübner, C. ; Erfle, V. ; Buff, K.

Exposure of HIV-infected cells to phospholipid leads to membrane alterations and selective growth retardation.

Biochim. Biophys. Acta-Mol. Basis Dis. 1139, 57-64 (1992)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The effect of exogenous phosphatidylcholine on structure and function of plasma membranes from HIV-1-producing cells and from their non-infected counterparts was determined. The membrane protein composition was not affected by phospholipid treatment. Membrane fluidity and Ca 2+-permeability were increased in virus-producing cells and in control cells after lipid treatment. The triacylglycerol content of the plasma membranes was increased in virus-producing cells after lipid treatment, whereas the content of phospholipid and cholesterol was not changed. The increased triacylglycerol content was in accordance with a relatively higher rate of [ 14C]oleic acid incorporation into triacylglycerols of the virus-producing cells after lipid treatment as shown by metabolic labeling. The results suggest that a latent cytopathic effect of HIV-infection becomes manifest if the cells are exposed to exogenous phospholipid and this may open a way to preferentially eliminate HIV-producing cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Ca 2+- ; Homeostasis ; Lipid Synthesis ; Membrane Fluidity ; Membrane Lipid Composition ; Phosphatidylcholine ; Triacylglycerol
ISSN (print) / ISBN 0925-4439
e-ISSN 1878-2434
Zeitschrift Biochimica et Biophysica Acta - Molecular Basis of Disease
Quellenangaben Band: 1139, Heft: 1-2, Seiten: 57-64 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Toxicology and Pharmacology (TOXI)