PuSH - Publikationsserver des Helmholtz Zentrums München: Decline in CD4<sup>+</sup> cell numbers in cats with naturally acquired feline immunodeficiency virus infection.

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Hoffmann-Fezer, G. ; Thum, J. ; Ackley, C.D.* ; Herbold, M. ; Mysliwietz, J. ; Thefeld, S. ; Hartmann, K.I.* ; Kraft, W.*

Decline in CD4⁺ cell numbers in cats with naturally acquired feline immunodeficiency virus infection.

J. Virol. 66, 1484-1488 (1992)

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T-cell subsets were studied by fluorescence-activated cell sorter analysis in 57 feline immunodeficiency virus (FIV)-seropositive cats with naturally acquired FIV infection to see whether CD4+-CD8+ alterations were comparable to those observed in human immunodeficiency virus-infected patients. CD4+ values were decreased and CD8+ values were increased. The CD4+/CD8+ ratio was reduced to 1.6, compared with 3.3 in 33 FIV-seronegative control cats. Variance analysis of data showed a significant influence of FIV seroposilivity, sex, and spaying of female cats on CD4+ values. CD8+ values were significantly influenced by FIV seropositivity, age, and breed. These findings indicate a similarity between FIV and human immunodeficiency virus infections, as far as alterations of T-cell subsets are concerned.

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PuSH - Publikationsserver des Helmholtz Zentrums München

Decline in CD4+ cell numbers in cats with naturally acquired feline immunodeficiency virus infection.

Decline in CD4⁺ cell numbers in cats with naturally acquired feline immunodeficiency virus infection.