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Pfab, F. ; Valet, M.* ; Tölle, T.* ; Behrendt, H. ; Ring, J. ; Darsow, U.

Recent progress in unraveling central nervous system processing of itch sensation.

World Allergy Organiz. J. 10, 168-173 (2008)
Verlagsversion DOI PMC
Open Access Gold
Itch is the major symptom of many allergic or inflammatory skin diseases, yet it is still difficult to measure objectively. This article shows and updates the development and approaches of central nervous system investigation of itch.Human neuroimaging studies on the physiology and pathophysiology of itch sensation have been hampered by the lack of a reproducible "on-off" stimulus. Short-term alternating temperature modulation of histamine-induced itch has recently been shown to provide on-off characteristics.Recent studies with functional magnetic resonance imaging demonstrate that itch sensation in healthy volunteers is processed by a network of brain regions contributing to the encoding of sensory, emotional, attentional, evaluative, and motivational aspects of itch.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter itch; cerebral processing; neuroimaging; histamine
e-ISSN 1939-4551
Zeitschrift World Allergy Organization Journal
Quellenangaben Band: 10, Heft: , Seiten: 168-173 Artikelnummer: , Supplement: ,
Verlag BioMed Central
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Environmental Dermatology and Allergology (ILBD-KAU)
Institute of Epidemiology (EPI)