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Schulz, H. ; Heilmann, P. ; Hillebrecht, A. ; Gebhart, J. ; Meyer, M.R. ; Piiper, J. ; Heyder, J.

Convective and diffusive gas transport in canine intrapulmonary airways.

J. Appl. Physiol. 72, 1557-1562 (1992)
PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The significance of convective and diffusive gas transport in the respiratory system was assessed from the response of combined inert gas and particle boluses inhaled into the conducting airways. Particles, considered as 'nondiffusing gas,' served as tracers for convection and two inert gases with widely different diffusive characteristics (He and SF6) as tracers for convection and diffusion. Six-milliliter boluses labeled with monodisperse di-2-ethylhexyl sebacate droplets of 0.86-μm aerodynamic diameter, 2% He, and 2% SF6 were inspired by three anesthetized mechanically ventilated beagle dogs to volumetric lung depths up to 170 ml. Mixing between inspired and residual air caused dispersion of the inspired bolus, which was quantified in terms of the bolus half-width. Dispersion of particles increased with increasing lung depth to which the boluses were inhaled. The increase followed a power law with exponents < 0.5 (mean 0.39), indicating that the effect of convective mixing per unit volume was reduced with depth. Within the pulmonary dead space, the behavior of the inert gases He and SF6 was similar to that of the particles, suggesting that gas transport was almost solely due to convection. Beyond the dead space, dispersion of He and SF6 increased more rapidly than dispersion of particles, indicating that diffusion became significant. The gas and particle bolus technique offers a suitable approach to differential analysis of gas transport in intrapulmonary airways of lungs.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Aerosol ; Combined Gas And Particle Bolus ; Convection ; Diffusion ; Helium ; Sulfur Hexafluoride ; Taylor Dispersion
ISSN (print) / ISBN 8750-7587
e-ISSN 1522-1601
Zeitschrift Journal of Applied Physiology
Quellenangaben Band: 72, Heft: 4, Seiten: 1557-1562 Artikelnummer: , Supplement: ,
Verlag American Physiological Society
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)